Each 2.5 ml unit-dose vial contains:
Levosalbutamol Sulphateâ¦â¦â¦â¦â¦â¦.1.25 mg
Ipratropium Bromide â¦â¦â¦â¦â¦â¦â¦â¦ 500 mcg
Normal Saline Solution, IP â¦â¦â¦â¦â¦............q.s.
Solution for inhalation via a nebulizer.
DUOLIN Respules is a combination of the beta2-adrenergic bronchodilator, levosalbutamol sulphate, and the anticholinergic bronchodilator, ipratropium bromide.
Levosalbutamol sulphate is a relatively selective beta2-adrenergic agonist, whose activation leads to an increase in intracellular adenyl cyclase, the enzyme which catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3`, 5`-adenosine monophosphate (cAMP).
Ipratropium bromide is an anticholinergic (parasympatholytic) agent, which inhibits vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
DUOLIN Respules.......... available as respule of 2.5 ml