Chlorpheniramine Maleate Tablets are frequently included in antihistamine trials for allergic skin disease. It is not one of the more effective antihistamines in dogs but is one of the most reliably effective antihistamines in the cat (in one study 73% of itchy cats responded). Its availability and inexpensiveness make it worth trying in many cases.
Mast cell tumors are tumors involving cells that contain granules of histamine. Patients with mast cell tumors experience chronic inflammatory symptoms due to circulating histamine. Antihistamines such as chlorpheniramine maleate may be helpful given long term.
Chlorpheniramine maleate has a strong anti-nausea side effect, which makes it helpful in treating motion sickness.
Chlorpheniramine maleate causes drowsiness in animals just as it does in people and can be used as a mild tranquilizer. Some argue that it is the drowsiness side effect that makes this medication appear to be helpful in itch management (i.e., patients scratch less because they are sleeping more.)
Convenient dosing makes it a common choice in the cat. It is often used in the management of feline asthma though its effectiveness in this condition is controversial.
Chlorpheniramine maleate is typically administered 2 to 3 times daily.
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